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Impact of NUDT15 genetics on severe thiopurine-related hematotoxicity in patients with European ancestry

6 Feb 2019

Abstract excerpt

PURPOSE: Severe hematotoxicity in patients with thiopurine therapy has been associated with genetic polymorphisms in the thiopurine S-methyltransferase (TPMT). While TPMT genetic testing is clinically implemented for dose individualization, alterations in the nudix hydrolase 15 (NUDT15) emerged as independent determinant of thiopurine-related hematotoxicity. Because data for European patients are limited, we...

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PMID: 30728528
DOI: 10.1038/s41436-019-0448-7

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