Article
Prevalence of polymorphisms in thiopurine metabolism and association with adverse outcomes: a South Asian region-specific systematic review and meta-analysis.
Expert review of clinical pharmacology - 1 Apr 2021
Jena Anuraag, Jha Daya Krishna, Kumar-M Praveen, Kasudhan Kripa Shanker, Kumar Ankit, Sarwal Dhruv, Mishra Shubhra, Singh Anupam Kumar, Bhatia Prateek, Patil Amol, Sharma Vishal
Abstract excerpt
Background: Prevalence and impact of thiopurine S-methyltransferase (TPMT) and Nudix hydrolase (NUDT15) minor allele frequencies in South Asian population is unclear.Methods: We searched PubMed and Embase with keywords-TPMT and NUDT15 combined with South Asian countries. We included studies reporting frequency of TPMT and NUDT15 polymorphisms. We estimated the pooled prevalence of TPMT and NUDT15 polymorphisms...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.