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Article

A novel single-tube multiplex real-time PCR assay for genotyping of thiopurine intolerance-causing variant NUDT15 c.415C>T.

Experimental biology and medicine (Maywood, N.J.) - 1 Sept 2021

Lian Xiaoyun, Li Yanwei, Li Lan, U Kaicheng, Wang Wenxia, Shi Yinmin, Ma Jiying, Wang Huijuan

Abstract excerpt

Thiopurines are commonly used in the treatment of acute lymphoblastic leukaemia and autoimmune conditions, can be limited by myelosuppression. The NUDT15 c.415C>T variant is strongly associated with thiopurine-induced myelosuppression, especially in Asians. The purpose of this study was to develop a fast and reliable genotyping method for NUDT15 c.415C>T and investigate the polymorphic distribution among...

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Identifiers

PMID: 34192970
DOI: 10.1177/15353702211026579
PMCID: PMC8474986

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A novel single-tube multiplex real-time PCR assay for genotyping of thiopurine intolerance-causing variant NUDT15 c.415C>T.PMID 34192970Read ↗

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