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Article

Super enhancers: Pathogenic roles and potential therapeutic targets for acute myeloid leukemia (AML)

23 Mar 2022

Abstract excerpt

Acute myeloid leukemia (AML) is a malignant hematological tumor with disordered oncogenes/tumor suppressor genes and limited treatments. The potent anti-cancer effects of bromodomain and extra-terminal domain (BET) inhibitors, targeting the key component of super enhancers, in early clinical trials on AML patients, implies the critical role of super enhancers in AML. Here, we review the concept and characteristic...

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PMID: 36157504
DOI: 10.1016/j.gendis.2022.01.006

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