Article
Mechanisms of epigenetic regulation of leukemia onset and progression.
Advances in immunology - 1 Jan 2013
Ntziachristos Panagiotis, Mullenders Jasper, Trimarchi Thomas, Aifantis Iannis
Abstract excerpt
Over the past decade, it has become clear that both genetics and epigenetics play pivotal roles in cancer onset and progression. The importance of epigenetic regulation in proper maintenance of cellular state is highlighted by the frequent mutation of chromatin modulating factors across cancer subtypes. Identification of these mutations has created an interest in designing drugs that target enzymes involved in...
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