Article
Exome sequencing of primary breast cancers with paired metastatic lesions reveals metastasis-enriched mutations in the A-kinase anchoring protein family (AKAPs).
BMC cancer - 12 Feb 2018
Kjällquist Una, Erlandsson Rikard, Tobin Nicholas P, Alkodsi Amjad, Ullah Ikram, Stålhammar Gustav, Karlsson Eva, Hatschek Thomas, Hartman Johan, Linnarsson Sten, Bergh Jonas
Abstract excerpt
BACKGROUND: Tumor heterogeneity in breast cancer tumors is today widely recognized. Most of the available knowledge in genetic variation however, relates to the primary tumor while metastatic lesions are much less studied. Many studies have revealed marked alterations of standard prognostic and predictive factors during tumor progression. Characterization of paired primary- and metastatic tissues should therefore...
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