Article

A Patient-Derived Xenograft Model Identifies AK1 as a Key Regulator of Metastatic Potential in Primary Triple-Negative Breast Cancer

2026-08-12

Abstract excerpt

<title>Abstract</title> Metastasis remains the major cause of mortality in triple-negative breast cancer (TNBC) 1,2 , yet the metastatic potential of primary tumors is difficult to predict at diagnosis 3,4 . Here, we leveraged patient-derived xenograft (PDX) models as a functional readout of primary tumor metastatic propensity. We first performed integrated genomic and transcriptomi...

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Literature Corpus work: 4790c08c-ce21-5bac-9527-2be79bbaee4c
DOI: 10.21203/rs.3.rs-10312219/v1

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