Article
Mutation Profiling of Key Cancer Genes in Primary Breast Cancers and Their Distant Metastases.
Cancer research - 15 Jun 2018
Schrijver Willemijne A M E, Selenica Pier, Lee Ju Youn, Ng Charlotte K Y, Burke Kathleen A, Piscuoglio Salvatore, Berman Samuel H, Reis-Filho Jorge S, Weigelt Britta, van Diest Paul J, Moelans Cathy B
Abstract excerpt
Although the repertoire of somatic genetic alterations of primary breast cancers has been extensively catalogued, the genetic differences between primary and metastatic tumors have been less studied. In this study, we compared somatic mutations and gene copy number alterations of primary breast cancers and their matched metastases from patients with estrogen receptor (ER)-negative disease. DNA samples obtained...
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