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Article

Genomic divergence between matched primary and metastatic tumors across cancer types: a pan-cancer analysis of 5,692 samples.

Expert review of anticancer therapy - 1 Apr 2026

Ergun Yakup

Abstract excerpt

BACKGROUND: Metastasis is the leading cause of cancer-related death and involves biological processes such as genomic instability and immune evasion. Although metastatic tumors generally retain major alterations present in primary tumors, the extent of additional genomic divergence across cancer types remains insufficiently characterized. RESEARCH DESIGN AND METHODS: A pan-cancer analysis was performed using...

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Identifiers

PMID: 41354463
DOI: 10.1080/14737140.2025.2601769

Genes

FGA
AR
CDKN2A
ESR1
KDM5A
MYC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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