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Article

Mutational Profile of Metastatic Breast Cancers: A Retrospective Analysis.

PLoS medicine - 1 Dec 2016

Lefebvre Celine, Bachelot Thomas, Filleron Thomas, Pedrero Marion, Campone Mario, Soria Jean-Charles, Massard Christophe, Lévy Christelle, Arnedos Monica, Lacroix-Triki Magali, Garrabey Julie, Boursin Yannick, Deloger Marc, Fu Yu, Commo Frédéric, Scott Véronique, Lacroix Ludovic, Dieci Maria Vittoria, Kamal Maud, Diéras Véronique, Gonçalves Anthony, Ferrerro Jean-Marc, Romieu Gilles, Vanlemmens Laurence, Mouret Reynier Marie-Ange, Théry Jean-Christophe, Le Du Fanny, Guiu Séverine, Dalenc Florence, Clapisson Gilles, Bonnefoi Hervé, Jimenez Marta, Le Tourneau Christophe, André Fabrice

Abstract excerpt

BACKGROUND: Major advances have been achieved in the characterization of early breast cancer (eBC) genomic profiles. Metastatic breast cancer (mBC) is associated with poor outcomes, yet limited information is available on the genomic profile of this disease. This study aims to decipher mutational profiles of mBC using next-generation sequencing. METHODS AND FINDINGS: Whole-exome sequencing was performed on 216...

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Identifiers

PMID: 28027327
DOI: 10.1371/journal.pmed.1002201
PMCID: PMC5189935

Genes

ESR1
AGRN
AKT1
ALK
CBFB
CDH1
ERBB4
FRAS1
FSIP2
GATA3
IGFN1
NOTCH3
OSBPL3
PALB2
PTEN
TSC1
TSC2

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