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Article

The genomic landscape of metastatic breast cancer: Insights from 11,000 tumors.

PloS one - 1 Jan 2020

Rinaldi Jacob, Sokol Ethan S, Hartmaier Ryan J, Trabucco Sally E, Frampton Garrett M, Goldberg Michael E, Albacker Lee A, Daemen Anneleen, Manning Gerard

Abstract excerpt

BACKGROUND: Metastatic breast cancer is the leading cause of cancer death in women, but the genomics of metastasis in breast cancer are poorly studied. METHODS: We explored a set of 11,616 breast tumors, including 5,034 metastases, which had undergone targeted sequencing during standard clinical care. RESULTS: Besides the known hotspot mutations in ESR1, we observed a metastatic enrichment of previously...

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Share to Estrogen Receptor alpha
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, erbB-2

Share to Germ-Line Mutation

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Source

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Identifiers

PMID: 32374727
DOI: 10.1371/journal.pone.0231999
PMCID: PMC7202592

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