Article
Molecular features of untreated breast cancer and initial metastatic event inform clinical decision-making and predict outcome: long-term results of ESOPE, a single-arm prospective multicenter study.
Genome medicine - 15 Mar 2021
Callens Céline, Driouch Keltouma, Boulai Anaïs, Tariq Zakia, Comte Aurélie, Berger Frédérique, Belin Lisa, Bièche Ivan, Servois Vincent, Legoix Patricia, Bernard Virginie, Baulande Sylvain, Chemlali Walid, Bidard François-Clément, Fourchotte Virginie, Salomon Anne Vincent-, Brain Etienne, Lidereau Rosette, Bachelot Thomas, Saghatchian Mahasti, Campone Mario, Giacchetti Sylvie, Zafrani Brigitte Sigal, Cottu Paul
Abstract excerpt
BACKGROUND: Prognosis evaluation of advanced breast cancer and therapeutic strategy are mostly based on clinical features of advanced disease and molecular profiling of the primary tumor. Very few studies have evaluated the impact of metastatic subtyping during the initial metastatic event in a prospective study. The genomic landscape of metastatic breast cancer has mostly been described in very advanced,...
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