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Article

Genetic Heterogeneity in Therapy-Naïve Synchronous Primary Breast Cancers and Their Metastases.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2017

Ng Charlotte K Y, Bidard Francois-Clement, Piscuoglio Salvatore, Geyer Felipe C, Lim Raymond S, de Bruijn Ino, Shen Ronglai, Pareja Fresia, Berman Samuel H, Wang Lu, Pierga Jean-Yves, Vincent-Salomon Anne, Viale Agnes, Norton Larry, Sigal Brigitte, Weigelt Britta, Cottu Paul, Reis-Filho Jorge S

Abstract excerpt

Purpose: Paired primary breast cancers and metachronous metastases after adjuvant treatment are reported to differ in their clonal composition and genetic alterations, but it is unclear whether these differences stem from the selective pressures of the metastatic process, the systemic therapies, or both. We sought to define the repertoire of genetic alterations in breast cancer patients with de novo metastatic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28351929
DOI: 10.1158/1078-0432.CCR-16-3115
PMCID: PMC5768571

Genes

GATA3
SMAD4
TCF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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