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Article

Upregulated galectin-3 is not a critical disease mediator of cardiomyopathy induced by β2-adrenoceptor overexpression.

American journal of physiology. Heart and circulatory physiology - 1 Jun 2018

Nguyen My-Nhan, Su Yidan, Kiriazis Helen, Yang Yan, Gao Xiao-Ming, McMullen Julie R, Dart Anthony M, Du Xiao-Jun

Abstract excerpt

Preclinical studies have demonstrated that anti-galectin-3 (Gal-3) interventions are effective in attenuating cardiac remodeling, fibrosis, and dysfunction. We determined, in a transgenic (TG) mouse model of fibrotic cardiomyopathy, whether Gal-3 expression was elevated and whether Gal-3 played a critical role in disease development. We studied mice with fibrotic cardiomyopathy attributable to cardiac...

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Source

Identifiers

PMID: 29424570
DOI: 10.1152/ajpheart.00337.2017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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