Article
Overexpression of P104L mutant caveolin-3 in mice develops hypertrophic cardiomyopathy with enhanced contractility in association with increased endothelial nitric oxide synthase activity.
Human molecular genetics - 15 Jan 2004
Ohsawa Yutaka, Toko Haruhiro, Katsura Masashi, Morimoto Kazue, Yamada Haruki, Ichikawa Yaeko, Murakami Tatsufumi, Ohkuma Seitaro, Komuro Issei, Sunada Yoshihide
Abstract excerpt
The effect of endogenous nitric oxide synthase (NOS) on cardiac contractility and architecture has been a matter of debate. A role for NOS in cardiac hypertrophy has recently been demonstrated by studies which have shown hypertrophic cardiomyopathy (HCM) with altered contractility in constitutive...
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