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Article

Lack of Gαi2 leads to dilative cardiomyopathy and increased mortality in β1-adrenoceptor overexpressing mice.

Cardiovascular research - 1 Dec 2015

Keller Kirsten, Maass Martina, Dizayee Sara, Leiss Veronika, Annala Suvi, Köth Jessica, Seemann Wiebke K, Müller-Ehmsen Jochen, Mohr Klaus, Nürnberg Bernd, Engelhardt Stefan, Herzig Stefan, Birnbaumer Lutz, Matthes Jan

Abstract excerpt

AIMS: Inhibitory G (Gi) proteins have been proposed to be cardioprotective. We investigated effects of Gαi2 knockout on cardiac function and survival in a murine heart failure model of cardiac β1-adrenoceptor overexpression. METHODS AND RESULTS: β1-transgenic mice lacking Gαi2 (β1-tg/Gαi2 (-/-)) were compared with wild-type mice and littermates either overexpressing cardiac β1-adrenoceptors (β1-tg) or lacking...

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Identifiers

PMID: 26464333
DOI: 10.1093/cvr/cvv235
PMCID: PMC4648201

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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