Article
Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age.
Proceedings of the National Academy of Sciences of the United States of America - 28 Oct 2003
Jacoby Jörg J, Kalinowski April, Liu Mu-Gen, Zhang Samuel S-M, Gao Qian, Chai Gui-Xuan, Ji Lan, Iwamoto Yoshiki, Li En, Schneider Michael, Russell Kerry S, Fu Xin-Yuan
Abstract excerpt
Cytokines and inflammation have been implicated in the pathogenesis of heart failure. For example, IL-6 family cytokines and the gp130 receptor play important roles in cardiac myocyte survival and hypertrophy. Signal transducer and activator of transcription 3 (STAT3) is a major signaling protein that is activated through gp130. We have created mice with a cardiomyocyte-restricted deletion of STAT3. As measured...
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