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Article

A transgenic mouse model of heart failure using inducible Galpha q.

The Journal of biological chemistry - 2 Dec 2005

Fan Gaofeng, Jiang Ya-Ping, Lu Zhongju, Martin Dwight W, Kelly Damon J, Zuckerman Joan M, Ballou Lisa M, Cohen Ira S, Lin Richard Z

Abstract excerpt

Receptors coupled to Galpha q play a key role in the development of heart failure. Studies using genetically modified mice suggest that Galpha q mediates a hypertrophic response in cardiac myocytes. Galpha q signaling in these models is modified during early growth and development, whereas most heart failure in humans occurs after cardiac damage sustained during adulthood. To determine the phenotype of animals...

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PMID: 16210321
DOI: 10.1074/jbc.M506810200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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