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Article

FoxO3 induces reversible cardiac atrophy and autophagy in a transgenic mouse model.

Cardiovascular research - 1 Sept 2011

Schips Tobias G, Wietelmann Astrid, Höhn Katharina, Schimanski Silvia, Walther Paul, Braun Thomas, Wirth Thomas, Maier Harald J

Abstract excerpt

AIMS: The transcription factor FoxO3 contributes to anti-hypertrophic signalling in the heart presumably by regulating autophagic-lysosomal and ubiquitin-proteasomal pathways. We wanted to study FoxO3 function in the adult heart in vivo by expressing a constitutively active mutant of FoxO3 in transgenic mice. METHODS AND RESULTS: We generated transgenic mice in which a tetracycline-regulated constitutively active...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forkhead Box Protein O3

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Share to TOR Serine-Threonine Kinases

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PMID: 21628326
DOI: 10.1093/cvr/cvr144

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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