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Article

Clinical characteristics and whole exome/transcriptome sequencing of coexisting chronic myeloid leukemia and myelofibrosis.

American journal of hematology - 1 Jun 2017

Kandarpa Malathi, Wu Yi-Mi, Robinson Dan, Burke Patrick William, Chinnaiyan Arul M, Talpaz Moshe

Abstract excerpt

Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell (HSC) disorders that can be classified on the basis of genetic, clinical, phenotypic features. Genetic lesions such as JAK2 mutations and BCR-ABL translocation are often mutually exclusive in MPN patients and lead to essential thrombocythemia, polycythemia vera, or myelofibrosis or chronic myeloid leukemia, respectively. Nevertheless,...

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Source

Identifiers

PMID: 28335073
DOI: 10.1002/ajh.24728

Genes

BCR
JAK2
ASXL1
BRAF
CALR
GNAS
IDH2
KRAS
MPL
SRSF2
TET2

Provenance

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