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Article

Vwf K1362A resulted in failure of protein synthesis in mice.

International journal of hematology - 1 Apr 2018

Sanda Naomi, Suzuki Nobuaki, Suzuki Atsuo, Kanematsu Takeshi, Kishimoto Mayuko, Hasuwa Hidetoshi, Takagi Akira, Kojima Tetsuhito, Matsushita Tadashi, Nakamura Shigeo

Abstract excerpt

Von Willebrand factor (VWF) is synthesized in megakaryocytes and endothelial cells (ECs) and has two main roles: to carry and protect coagulation factor VIII (FVIII) from degradation by forming VWF-FVIII complex; and to mediate platelet adhesion and aggregation at sites of vascular injury. Previous research using the HEK293 cell line revealed that the VWF K1362 mutation interacted directly with platelet...

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Identifiers

PMID: 29392565
DOI: 10.1007/s12185-017-2394-y

Genes

VWF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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