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Article

Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice.

Blood - 4 Aug 2016

Shaw Maureen A, Kombrinck Keith W, McElhinney Kathryn E, Sweet David R, Flick Matthew J, Palumbo Joseph S, Cheng Mei, Esmon Naomi L, Esmon Charles T, Brill Alexander, Wagner Denisa D, Degen Jay L, Mullins Eric S

Abstract excerpt

Thrombin-mediated proteolysis is central to hemostatic function but also plays a prominent role in multiple disease processes. The proteolytic conversion of fII to α-thrombin (fIIa) by the prothrombinase complex occurs through 2 parallel pathways: (1) the inactive intermediate, prethrombin; or (2) the proteolytically active intermediate, meizothrombin (fIIa(MZ)). FIIa(MZ) has distinct catalytic properties...

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Identifiers

PMID: 27252233
DOI: 10.1182/blood-2015-11-680280
PMCID: PMC4974202

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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