Article
Targeted inactivation of the mouse locus encoding coagulation factor XIII-A: hemostatic abnormalities in mutant mice and characterization of the coagulation deficit.
Thrombosis and haemostasis - 1 Dec 2002
Lauer Peter, Metzner Hubert J, Zettlmeissl Gerd, Li Meng, Smith Austin G, Lathe Richard, Dickneite Gerhard
Abstract excerpt
Blood coagulation factor XIII (FXIII) promotes cross-linking of fibrin during blood coagulation; impaired clot stabilization in human genetic deficiency is associated with marked pathologies of major clinical impact, including bleeding symptoms and deficient wound healing. To investigate the role of FXIII we employed homologous recombination to generate a targeted deletion of the inferred exon 7 of the FXIII-A...
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