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Article

Placental Vascular Defects and Embryonic Lethality Triggered by TFPIα Deficiency in Factor V Leiden Mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2025

Siebert Amy E, Maroney Susan A, Martinez Nicholas D, Soares Michael J, Mast Alan E

Abstract excerpt

BACKGROUND: TFPI (tissue factor pathway inhibitor) inhibits the initiation of blood coagulation. TFPIα (TFPI alpha isoform), the only alternatively spliced TFPI isoform in platelets, is abundant in placenta and uniquely inhibits prothrombinase (FXa [activated factor X]-FVa [activated factor V]). This inhibitory activity is reduced when prothrombinase is assembled with FVL (factor V Leiden). METHODS: Effects of...

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Identifiers

PMID: 40401373
DOI: 10.1161/ATVBAHA.125.322650
PMCID: PMC12197823

Genes

TFPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Placental Vascular Defects and Embryonic Lethality Triggered by TFPIα Deficiency in Factor V Leiden Mice.PMID 40401373Read ↗

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