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Article

Expression of a structurally constrained von Willebrand factor variant triggers acute thrombotic thrombocytopenic purpura in mice.

Blood - 22 May 2014

Morioka Yoko, Casari Caterina, Wohner Nikolett, Cho Sungyun, Kurata Sachiko, Kitano Ayumi, Christophe Olivier D, Lenting Peter J, Li Renhao, Denis Cécile V, Prévost Nicolas

Abstract excerpt

Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease that presents with thrombocytopenia, disseminated thrombosis, hemolytic anemia, and organ dysfunction. The etiology of TTP has revealed that patients share a deficiency in plasma protease a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13), the enzyme responsible for cleaving ultra-large von Willebrand...

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Source

Identifiers

PMID: 24713928
DOI: 10.1182/blood-2013-10-531392

Genes

VWF
ADAMTS13

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Expression of a structurally constrained von Willebrand factor variant triggers acute thrombotic thrombocytopenic purpura in mice.PMID 24713928Read ↗

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