Article

A Novel VWF Knockout Endothelial Cell Model to study von Willebrand Factor Biology and Von Willebrand Disease Mechanisms

2026-04-03

Abstract excerpt

Understanding how specific VWF variants disrupt endothelial processing and function is central to elucidating von Willebrand disease (VWD) pathophysiology. However, current in vitro systems lack either the endothelial specificity or the genetic flexibility required for systematic variant characterization. Here, we present a genetically defined VWF-knockout cord-blood–derived endothelial colony-forming cell (VWF-KO...

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Literature Corpus work: 2ad25936-24c7-5a9d-a2d7-79fc48cce00c
DOI: 10.64898/2026.04.01.715845

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