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Article

Characterization of a genetically engineered mouse model of hemophilia A with complete deletion of the F8 gene.

Journal of thrombosis and haemostasis : JTH - 1 Feb 2016

Chao B N, Baldwin W H, Healey J F, Parker E T, Shafer-Weaver K, Cox C, Jiang P, Kanellopoulou C, Lollar P, Meeks S L, Lenardo M J

Abstract excerpt

UNLABELLED: ESSENTIALS: Anti-factor VIII (FVIII) inhibitory antibody formation is a severe complication in hemophilia A therapy. We genetically engineered and characterized a mouse model with complete deletion of the F8 coding region. F8(TKO) mice exhibit severe hemophilia, express no detectable F8 mRNA, and produce FVIII inhibitors. The defined background and lack of FVIII in F8(TKO) mice will aid in studying...

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Identifiers

PMID: 26588198
DOI: 10.1111/jth.13202
PMCID: PMC4755856

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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