Article
A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis.
Proceedings of the National Academy of Sciences of the United States of America - 4 Aug 1998
Denis C, Methia N, Frenette P S, Rayburn H, Ullman-Culleré M, Hynes R O, Wagner D D
Abstract excerpt
von Willebrand factor (vWf) deficiency causes severe von Willebrand disease in humans. We generated a mouse model for this disease by using gene targeting. vWf-deficient mice appeared normal at birth; they were viable and fertile. Neither vWf nor vWf propolypeptide (von Willebrand antigen II) wer...
Topics
- Animals
- Disease Models, Animal
- Female
- Hemostasis
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Phenotype
- Thrombosis
- von Willebrand Diseases
- von Willebrand Factor