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Article

A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis.

Proceedings of the National Academy of Sciences of the United States of America - 4 Aug 1998

Denis C, Methia N, Frenette P S, Rayburn H, Ullman-Culleré M, Hynes R O, Wagner D D

Abstract excerpt

von Willebrand factor (vWf) deficiency causes severe von Willebrand disease in humans. We generated a mouse model for this disease by using gene targeting. vWf-deficient mice appeared normal at birth; they were viable and fertile. Neither vWf nor vWf propolypeptide (von Willebrand antigen II) were detectable in plasma, platelets, or endothelial cells of the homozygous mutant mice. The mutant mice exhibited...

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Identifiers

PMID: 9689113
DOI: 10.1073/pnas.95.16.9524
PMCID: PMC21371

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Source receipt: pubmed, retrieved 7 Sept 2026.

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