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Article

Use of a mouse model to elucidate the phenotypic effects of the von Willebrand factor cleavage mutants, Y1605A/M1606A and R1597W.

Journal of thrombosis and haemostasis : JTH - 1 May 2012

Pruss C M, Golder M, Bryant A, Hegadorn C, Haberichter S, Lillicrap D

Abstract excerpt

BACKGROUND: von Willebrand Factor (VWF) is tightly regulated by the metalloproteinase ADAMTS13, which cleaves VWF to reduce VWF multimer size and binding affinity for collagen and platelets. OBJECTIVE: This study examines two VWF mutations, R1597W (enhanced cleavage) and Y1605A-M1606A (decreased cleavage), to determine their impact on VWF, in addition to ADAMTS13-mediated cleavage. METHODS: In vitro mouse...

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Source

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Identifiers

PMID: 22372972
DOI: 10.1111/j.1538-7836.2012.04675.x
PMCID: PMC5962034

Genes

VWF
ADAMTS13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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