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Article

Defective thrombus formation in mice lacking endogenous factor VII activating protease (FSAP).

Thrombosis and haemostasis - 1 Apr 2015

Subramaniam Saravanan, Thielmann Ina, Morowski Martina, Pragst Ingo, Sandset Per Morten, Nieswandt Bernhard, Etscheid Michael, Kanse Sandip M

Abstract excerpt

Factor VII (FVII) activating protease (FSAP) is a circulating protease with a putative function in blood coagulation and fibrinolysis. Genetic epidemiological studies have implied a role for FSAP in carotid stenosis, stroke and thrombosis. To date, no in vivo evidence is available to support these claims. We have, for the first time, used FSAP-/- mice to define its role in thrombosis and haemostasis in vivo and...

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Identifiers

PMID: 25427855
DOI: 10.1160/TH14-06-0519

Genes

TFPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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