Article
The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling.
Nature communications - 3 Nov 2015
Klein Theo, Fung Shan-Yu, Renner Florian, Blank Michael A, Dufour Antoine, Kang Sohyeong, Bolger-Munro Madison, Scurll Joshua M, Priatel John J, Schweigler Patrick, Melkko Samu, Gold Michael R, Viner Rosa I, Régnier Catherine H, Turvey Stuart E, Overall Christopher M
Abstract excerpt
Antigen receptor signalling activates the canonical NF-κB pathway via the CARD11/BCL10/MALT1 (CBM) signalosome involving key, yet ill-defined roles for linear ubiquitination. The paracaspase MALT1 cleaves and removes negative checkpoint proteins, amplifying lymphocyte responses in NF-κB activation and in B-cell lymphoma subtypes. To identify new human MALT1 substrates, we compare B cells from the only known...
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