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Article

Structural determinants of MALT1 protease activity.

Journal of molecular biology - 25 May 2012

Wiesmann Christian, Leder Lukas, Blank Jutta, Bernardi Anna, Melkko Samu, Decock Arnaud, D'Arcy Allan, Villard Frederic, Erbel Paulus, Hughes Nicola, Freuler Felix, Nikolay Rainer, Alves Juliano, Bornancin Frederic, Renatus Martin

Abstract excerpt

The formation of the CBM (CARD11-BCL10-MALT1) complex is pivotal for antigen-receptor-mediated activation of the transcription factor NF-κB. Signaling is dependent on MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1), which not only acts as a scaffolding protein but also possesses proteolytic activity mediated by its caspase-like domain. It remained unclear how the CBM activates MALT1....

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Share to Caspases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22366302
DOI: 10.1016/j.jmb.2012.02.018

Genes

MALT1
BCL10
CARD11

Provenance

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