Article
BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL.
Cancer discovery - 5 Aug 2022
Xia Min, David Liron, Teater Matt, Gutierrez Johana, Wang Xiang, Meydan Cem, Lytle Andrew, Slack Graham W, Scott David W, Morin Ryan D, Onder Ozlem, Elenitoba-Johnson Kojo S J, Zamponi Nahuel, Cerchietti Leandro, Lu Tianbao, Philippar Ulrike, Fontan Lorena, Wu Hao, Melnick Ari M
Abstract excerpt
Activated B cell-like diffuse large B-cell lymphomas (ABC-DLBCL) have unfavorable outcomes and chronic activation of CARD11-BCL10-MALT1 (CBM) signal amplification complexes that form due to polymerization of BCL10 subunits, which is affected by recurrent somatic mutations in ABC-DLBCLs. Herein, we show that BCL10 mutants fall into at least two functionally distinct classes: missense mutations of the BCL10 CARD...
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