Article

A nucleation barrier spring-loads the CBM signalosome for binary activation

2022-01-29

Abstract excerpt

Immune cells activate in a binary, switch-like fashion that involves proteins polymerizing into large complexes known as signalosomes. The switch-like nature of signalosome formation has been proposed to result from large energy barriers to polymer nucleation. Whether such nucleation barriers indeed drive binary immune responses has not yet been shown. Here, we employed an in-cell biophysical approach to dissect t...

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Literature Corpus work: abd230e7-8549-5d12-a192-57c8266e7982
DOI: 10.1101/2022.01.28.477912

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