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Article

hmSOD1 gene mutation-induced disturbance in iron metabolism is mediated by impairment of Akt signalling pathway.

Journal of cachexia, sarcopenia and muscle - 1 Jun 2018

Halon-Golabek Malgorzata, Borkowska Andzelika, Kaczor Jan J, Ziolkowski Wieslaw, Flis Damian J, Knap Narcyz, Kasperuk Kajetan, Antosiewicz Jedrzej

Abstract excerpt

BACKGROUND: Recently, skeletal muscle atrophy, impairment of iron metabolism, and insulin signalling have been reported in rats suffering from amyotrophic lateral sclerosis (ALS). However, the interrelationship between these changes has not been studied. We hypothesize that an impaired Akt-FOXO3a signalling pathway triggers changes in the iron metabolism in the muscles of transgenic animals. METHODS: In the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29380557
DOI: 10.1002/jcsm.12283
PMCID: PMC5989766

Genes

SOD1
APP
PCBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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