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Article

Changes in skeletal muscle iron metabolism outpace amyotrophic lateral sclerosis onset in transgenic rats bearing the G93A hmSOD1 gene mutation.

Free radical research - 1 Nov 2014

Halon M, Kaczor J J, Ziolkowski W, Flis D J, Borkowska A, Popowska U, Nyka W, Wozniak M, Antosiewicz J

Abstract excerpt

OBJECTIVE: Recently, iron and the adaptor protein "p66Shc" have been shown to play an important role in the development of amyotrophic lateral sclerosis (ALS) in rats. We hypothesized that changes in muscle p66Shc activity and iron metabolism would appear before visible symptoms of the disease occurred. METHODS: In the present study, we used transgenic rats bearing the G93A hmSOD1 gene mutation and their...

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PMID: 25175826
DOI: 10.3109/10715762.2014.955484

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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