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Article

Skeletal muscle is a primary target of SOD1G93A-mediated toxicity.

Cell metabolism - 1 Nov 2008

Dobrowolny Gabriella, Aucello Michela, Rizzuto Emanuele, Beccafico Sara, Mammucari Cristina, Boncompagni Simona, Bonconpagni Simona, Belia Silvia, Wannenes Francesca, Nicoletti Carmine, Del Prete Zaccaria, Rosenthal Nadia, Molinaro Mario, Protasi Feliciano, Fanò Giorgio, Sandri Marco, Musarò Antonio

Abstract excerpt

The antioxidant enzyme superoxide dismutase 1 (SOD1) is a critical player of the antioxidative defense whose activity is altered in several chronic diseases, including amyotrophic lateral sclerosis. However, how oxidative insult affects muscle homeostasis remains unclear. This study addresses the...

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Source

Identifiers

PMID: 19046573
DOI: 10.1016/j.cmet.2008.09.002

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19046573-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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