Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington’s disease

4 Jul 2018

Abstract excerpt

BACKGROUND: Iron accumulation in basal ganglia accompanies neuronal loss in Huntington's disease (HD) patients and mouse disease models. Disruption of HD brain iron homeostasis occurs before the onset of clinical signs. Therefore, investigating the mechanism of iron accumulation is essential to understanding its role in disease pathogenesis. METHODS: N171-82Q HD transgenic mice brain iron was detected by using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis Research
Share to Fibromyalgia and Chronic Fatigue Syndrome Research
Share to Genetic Neurodegenerative Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30002810
DOI: 10.1186/s13578-018-0239-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington’s diseasePMID 30002810Read ↗

Iron dysregulation in Huntington's disease.Semantic proximity Read ↗

H63D variant of the homeostatic iron regulator (HFE) gene alters α-synuclein expression, aggregation, and toxicity.Semantic proximity Read ↗

Dysregulation of iron homeostasis in the CNS contributes to disease progression in a mouse model of amyotrophic lateral sclerosis.Semantic proximity Read ↗

A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin.Semantic proximity Read ↗

Molecular genetic approaches to understanding the roles and regulation of iron in brain health and disease.Semantic proximity Read ↗

Brain Iron Metabolism and Neurodegenerative DisordersSemantic proximity Read ↗

The roles of iron and HFE genotype in neurological diseases.Semantic proximity Read ↗

Neurodegeneration with Brain Iron Accumulation Disorders: Valuable Models Aimed at Understanding the Pathogenesis of Iron DepositionSemantic proximity Read ↗

A mouse model of hemochromatosis-related mutations with brain iron dyshomeostasis exhibits loss of tyrosine hydroxylase expression in dopaminergic neurons and motor control impairment relevant to Parkinson’s diseaseSemantic proximity Read ↗

Neurodegeneration with brain iron accumulation.Semantic proximity Read ↗

β-Propeller protein-associated neurodegeneration: a new X-linked dominant disorder with brain iron accumulation.Semantic proximity Read ↗

Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.