Article

Comprehensive characterization of skeletal muscle remodeling in <i> hSOD1 <sup>G93A</sup> </i> mice reveals limited functional impact of systemic FOXO1 inhibition

2026-05-31

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motor neuron (MN) loss, muscle atrophy and paralysis. Although traditionally considered a MN-specific disease, accumulating evidence supports a crucial contribution of skeletal muscle pathology to disease onset and progression. Except for specific mutations, to date there i...

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Literature Corpus work: 28e8d6c3-cff0-556e-a0ff-9aef2ba5e3ff
DOI: 10.64898/2026.05.27.726208

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