Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

H63D HFE genotype accelerates disease progression in animal models of amyotrophic lateral sclerosis.

Biochimica et biophysica acta - 1 Dec 2014

Nandar Wint, Neely Elizabeth B, Simmons Zachary, Connor James R

Abstract excerpt

H63D HFE is associated with iron dyshomeostasis and oxidative stress; each of which plays an important role in amyotrophic lateral sclerosis (ALS) pathogenesis. To examine the role of H63D HFE in ALS, we generated a double transgenic mouse line (SOD1/H67D) carrying the H67D HFE (homologue of human H63D) and SOD1(G93A) mutations. We found double transgenic mice have shorter survival and accelerated disease...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoferritins
Share to Caspase 3
Share to Gliosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemochromatosis Protein

Share to Motor Activity

Share to Motor Neurons

Share to Superoxide Dismutase

Share to Superoxide Dismutase-1

Source

Identifiers

PMID: 25283820
DOI: 10.1016/j.bbadis.2014.09.016

Genes

HFE
SOD1
GFAP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

H63D HFE genotype accelerates disease progression in animal models of amyotrophic lateral sclerosis.PMID 25283820Read ↗

HFE Mutations in Neurodegenerative Disease as a Model of Hormesis.Semantic proximity Read ↗

Expression of a mutant form of the ferritin light chain gene induces neurodegeneration and iron overload in transgenic mice.Semantic proximity Read ↗

HFE Genotype Restricts the Response to Paraquat in a Mouse Model of Neurotoxicity.Semantic proximity Read ↗

H63D variant of the homeostatic iron regulator (HFE) gene alters α-synuclein expression, aggregation, and toxicity.Semantic proximity Read ↗

The roles of iron and HFE genotype in neurological diseases.Semantic proximity Read ↗

Mouse brains deficient in H-ferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stress.Semantic proximity Read ↗

Dysregulation of iron homeostasis in the CNS contributes to disease progression in a mouse model of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Changes in skeletal muscle iron metabolism outpace amyotrophic lateral sclerosis onset in transgenic rats bearing the G93A hmSOD1 gene mutation.Semantic proximity Read ↗

A hemochromatosis allele that protects against Alzheimer's disease injury: A role for H-ferritin.Semantic proximity Read ↗

A mouse model of hemochromatosis-related mutations with brain iron dyshomeostasis exhibits loss of tyrosine hydroxylase expression in dopaminergic neurons and motor control impairment relevant to Parkinson’s diseaseSemantic proximity Read ↗

Effect of Systemic Iron Overload and a Chelation Therapy in a Mouse Model of the Neurodegenerative Disease Hereditary FerritinopathySemantic proximity Read ↗

Retrospective Study of the Physiological and Molecular Features of the S-FUS (1-359) Mouse Transgenic Model with an ALS-like Phenotype: Lifespan, Body Weight Dynamics, Movement Disorders, and Dysregulation of the Dopaminergic System.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.