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Article

Fisetin Exerts Antioxidant and Neuroprotective Effects in Multiple Mutant hSOD1 Models of Amyotrophic Lateral Sclerosis by Activating ERK.

Neuroscience - 21 May 2018

Wang T H, Wang S Y, Wang X D, Jiang H Q, Yang Y Q, Wang Y, Cheng J L, Zhang C T, Liang W W, Feng H L

Abstract excerpt

Oxidative stress exhibits a central role in the course of amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease commonly found to include a copper/zinc superoxide dismutase (SOD1) gene mutation. Fisetin, a natural antioxidant, has shown benefits in varied neurodegenerative diseases. The possible effect of fisetin in ALS has not been clarified as of yet. We investigated whether fisetin...

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PMID: 29559385
DOI: 10.1016/j.neuroscience.2018.03.008

Genes

SOD1

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