Article
Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis.
Circulation research - 31 Jul 2020
Fang Xuexian, Cai Zhaoxian, Wang Hao, Han Dan, Cheng Qi, Zhang Pan, Gao Feng, Yu Yingying, Song Zijun, Wu Qian, An Peng, Huang Sicong, Pan Jianwei, Chen Hou-Zao, Chen Jinghai, Linkermann Andreas, Min Junxia, Wang Fudi
Abstract excerpt
RATIONALE: Maintaining iron homeostasis is essential for proper cardiac function. Both iron deficiency and iron overload are associated with cardiomyopathy and heart failure via complex mechanisms. Although ferritin plays a central role in iron metabolism by storing excess cellular iron, the molecular function of ferritin in cardiomyocytes remains unknown. OBJECTIVE: To characterize the functional role of Fth...
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