Article
Loss in Toxic Function of Aggregates of α -Synuclein Mutants by a β-Synuclein Derived Peptide.
Protein and peptide letters - 1 Jan 2017
Mohammadi Soheila, Nikkhah Maryam, Hosseinkhani Saman
Abstract excerpt
BACKGROUND: Parkinson's disease (PD) primarily results from a severe and selective damage of dopaminergic neurons. The neuropathological hallmark of the disease is the presence of protein inclusions of α-Synuclein (αS) within the surviving neurons. To date, several researchers have been focused on screening for the inhibitors that are able to block, slow down, or reverse αS aggregation, particularly at its early...
Topics
- Amino Acid Sequence
- Cell Line, Tumor
- Cell Survival
- Cloning, Molecular
- Escherichia coli
- Gene Expression
- Humans
- Mutation
- Neurons
- Peptides
- Plasmids
- Protein Aggregates