Article
Profilin reduces aggregation and phase separation of huntingtin N-terminal fragments by preferentially binding to soluble monomers and oligomers.
The Journal of biological chemistry - 9 Mar 2018
Posey Ammon E, Ruff Kiersten M, Harmon Tyler S, Crick Scott L, Li Aimin, Diamond Marc I, Pappu Rohit V
Abstract excerpt
Huntingtin N-terminal fragments (Htt-NTFs) with expanded polyglutamine tracts form a range of neurotoxic aggregates that are associated with Huntington's disease. Here, we show that aggregation of Htt-NTFs, irrespective of polyglutamine length, yields at least three phases (designated M, S, and F) that are delineated by sharp concentration thresholds and distinct aggregate sizes and morphologies. We found that...
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