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Article

Protofilament Structure and Supramolecular Polymorphism of Aggregated Mutant Huntingtin Exon 1.

Journal of molecular biology - 24 Jul 2020

Boatz Jennifer C, Piretra Talia, Lasorsa Alessia, Matlahov Irina, Conway James F, van der Wel Patrick C A

Abstract excerpt

Huntington's disease is a progressive neurodegenerative disease caused by expansion of the polyglutamine domain in the first exon of huntingtin (HttEx1). The extent of expansion correlates with disease progression and formation of amyloid-like protein deposits within the brain. The latter display polymorphism at the microscopic level, both in cerebral tissue and in vitro. Such polymorphism can dramatically...

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Identifiers

PMID: 32598938
DOI: 10.1016/j.jmb.2020.06.021
PMCID: PMC8170701

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Protofilament Structure and Supramolecular Polymorphism of Aggregated Mutant Huntingtin Exon 1.PMID 32598938Read ↗

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