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Article

Cyclin A-Cdk1 regulates the origin firing program in mammalian cells.

Proceedings of the National Academy of Sciences of the United States of America - 3 Mar 2009

Katsuno Yuko, Suzuki Ayumi, Sugimura Kazuto, Okumura Katsuzumi, Zineldeen Doaa H, Shimada Midori, Niida Hiroyuki, Mizuno Takeshi, Hanaoka Fumio, Nakanishi Makoto

Abstract excerpt

Somatic mammalian cells possess well-established S-phase programs with specific regions of the genome replicated at precise times. The ATR-Chk1 pathway plays a central role in these programs, but the mechanism for how Chk1 regulates origin firing remains unknown. We demonstrate here the essential role of cyclin A2-Cdk1 in the regulation of late origin firing. Activity of cyclin A2-Cdk1 was hardly detected at the...

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Identifiers

PMID: 19221029
DOI: 10.1073/pnas.0809350106
PMCID: PMC2651338

Genes

ATR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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