Article
Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM.
Nature structural & molecular biology - 1 Jan 2018
Hughes Taylor E T, Lodowski David T, Huynh Kevin W, Yazici Aysenur, Del Rosario John, Kapoor Abhijeet, Basak Sandip, Samanta Amrita, Han Xu, Chakrapani Sudha, Zhou Z Hong, Filizola Marta, Rohacs Tibor, Han Seungil, Moiseenkova-Bell Vera Y
Abstract excerpt
The transient receptor potential vanilloid 5 (TRPV5) channel is a member of the transient receptor potential (TRP) channel family, which is highly selective for Ca2+, that is present primarily at the apical membrane of distal tubule epithelial cells in the kidney and plays a key role in Ca2+ reabsorption. Here we present the structure of the full-length rabbit TRPV5 channel as determined using cryo-EM in complex...
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