Structural insights into TRPV4-Rho GTPase signaling complex function and disease

Abstract excerpt

Crosstalk between ion channels and small GTPases is critical during homeostasis and disease 1 , but little is known about the structural underpinnings of these interactions. TRPV4 is a polymodal, calcium-permeable cation channel that has emerged as a potential therapeutic target in multiple conditions 2–5 . Gain-of-function mutations also cause hereditary neuromuscular disease 6–11 . Here, we present cryo-EM st...

Topics

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• Adenosine Triphosphate
• Ankyrin Repeat
• Calcium
• Channelopathies
• Disease
• Mutation
• rhoA GTP-Binding Protein
• TRPV Cation Channels

Identifiers and source

Literature Corpus work

99d26f6c-78c3-5eee-afad-9b25ce2678ee

DOI

10.1101/2023.03.15.532784