Structural basis of TRPV3 inhibition by an antagonist.

Abstract excerpt

The TRPV3 channel plays vital roles in skin physiology. Dysfunction of TRPV3 causes skin diseases, including Olmsted syndrome. However, the lack of potent and selective inhibitors impedes the validation of TRPV3 as a therapeutic target. In this study, we identified Trpvicin as a potent and subtype-selective inhibitor of TRPV3. Trpvicin exhibits pharmacological potential in the inhibition of itch and hair loss in...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Binding Sites
• Share to Mice
• Share to Mutation