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Article

A Novel Mechanism for Calmodulin-Dependent Inactivation of Transient Receptor Potential Vanilloid 6.

Biochemistry - 8 May 2018

Bate Neil, Caves Rachel E, Skinner Simon P, Goult Benjamin T, Basran Jaswir, Mitcheson John S, Vuister Geerten W

Abstract excerpt

The paralogues TRPV5 and TRPV6 belong to the vanilloid subfamily of the transient receptor potential (TRP) superfamily of ion channels, and both play an important role in overall Ca2+ homeostasis. The functioning of the channels centers on a tightly controlled Ca2+-dependent feedback mechanism in which the direct binding of the universal Ca2+-binding protein calmodulin (CaM) to the channel's C-terminal tail is...

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Source

Identifiers

PMID: 29505720
DOI: 10.1021/acs.biochem.7b01286

Genes

TRPV6
TRPV5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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